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KMID : 0378019670100060109
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New Medical Journal
1967 Volume.10 No. 6 p.109 ~ p.123
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An Experimental Study on Schwartzman Phenomenon
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Abstract
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In 1928 Schwartzman reported on a hemorrhagic and often necrotic cutaneous lesion in a bacterial filtrate presensitized rabbit, produced by injecting same filtrate into the animal intravenously. Later, it was found that agents used for sensitization and subsequent provocation need not be same in antigenic property, that is, there is no specificity between the agents used for preparatory injection and provocation.
The author conducted a series of experiments concerning Schwartzman phenomenon in a foreign protein sensitized rabbits.
The animals were sensitized by means of repeated intravenous injection of egg white over prolonged period. Prior to each subsequent sensitization, blood specimen was withdrawn for the measurement of circulating pricipitin. Then certain cutaneous area of these animals were prepared with bacterial culture filtrate and intravenous provocations with egg white were carried out 24 hours later, with following results.
The author could elicit Schwartzman phenomenon in a majority of experimental animal and the severity of ;cutaneous lesion seemed to parallel with the number of egg white injection prior to the elicitation of Schwartzman phenomenon. The.severity of Schwartzman phenomenon also had close relationship with the amount of -circulating pricipitin in the sensitized animal, suggesting Schwartzman phenomenon has allergic process as its ultimate pathogenesis.
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